diff --git a/src/changelog/unreleased.md b/src/changelog/unreleased.md
index c839df5f3..5f15e1b6a 100644
--- a/src/changelog/unreleased.md
+++ b/src/changelog/unreleased.md
@@ -65,3 +65,4 @@ changelog entry.
 - On macOS, fixed `run_app_on_demand` returning without closing open windows.
 - On macOS, fixed `VideoMode::refresh_rate_millihertz` for fractional refresh rates.
 - On macOS, store monitor handle to avoid panics after going in/out of sleep.
+- On macOS, allow certain invalid monitor handles and return `None` instead of panicking.
diff --git a/src/platform_impl/macos/monitor.rs b/src/platform_impl/macos/monitor.rs
index 7d17ca2b7..44e6316b6 100644
--- a/src/platform_impl/macos/monitor.rs
+++ b/src/platform_impl/macos/monitor.rs
@@ -291,17 +291,24 @@ impl MonitorHandle {
         unsafe {
             let modes = {
                 let array = ffi::CGDisplayCopyAllDisplayModes(self.display_id(), std::ptr::null());
-                assert!(!array.is_null(), "failed to get list of display modes");
-                let array_count = CFArrayGetCount(array);
-                let modes: Vec<_> = (0..array_count)
-                    .map(move |i| {
-                        let mode = CFArrayGetValueAtIndex(array, i) as *mut _;
-                        ffi::CGDisplayModeRetain(mode);
-                        mode
-                    })
-                    .collect();
-                CFRelease(array as *const _);
-                modes
+                if array.is_null() {
+                    // Occasionally, certain CalDigit Thunderbolt Hubs report a spurious monitor
+                    // during sleep/wake/cycling monitors. It tends to have null
+                    // or 1 video mode only. See <https://github.com/bevyengine/bevy/issues/17827>.
+                    warn!(monitor = ?self, "failed to get a list of display modes");
+                    Vec::new()
+                } else {
+                    let array_count = CFArrayGetCount(array);
+                    let modes: Vec<_> = (0..array_count)
+                        .map(move |i| {
+                            let mode = CFArrayGetValueAtIndex(array, i) as *mut _;
+                            ffi::CGDisplayModeRetain(mode);
+                            mode
+                        })
+                        .collect();
+                    CFRelease(array as *const _);
+                    modes
+                }
             };
 
             modes.into_iter().map(move |mode| {
@@ -346,9 +353,14 @@ impl MonitorHandle {
         let uuid = self.uuid();
         NSScreen::screens(mtm).into_iter().find(|screen| {
             let other_native_id = get_display_id(screen);
-            // Display ID just fetched from live NSScreen, should be fine to unwrap.
-            let other = MonitorHandle::new(other_native_id).expect("invalid display ID");
-            uuid == other.uuid()
+            if let Some(other) = MonitorHandle::new(other_native_id) {
+                uuid == other.uuid()
+            } else {
+                // Display ID was just fetched from live NSScreen, but can still result in `None`
+                // with certain Thunderbolt docked monitors.
+                warn!(other_native_id, "comparing against screen with invalid display ID");
+                false
+            }
         })
     }
 }
diff --git a/src/platform_impl/macos/window_delegate.rs b/src/platform_impl/macos/window_delegate.rs
index abc140230..e0dc693c5 100644
--- a/src/platform_impl/macos/window_delegate.rs
+++ b/src/platform_impl/macos/window_delegate.rs
@@ -1592,8 +1592,14 @@ impl WindowDelegate {
     // Allow directly accessing the current monitor internally without unwrapping.
     pub(crate) fn current_monitor_inner(&self) -> Option<MonitorHandle> {
         let display_id = get_display_id(&*self.window().screen()?);
-        // Display ID just fetched from live NSScreen, should be fine to unwrap.
-        Some(MonitorHandle::new(display_id).expect("invalid display ID"))
+        if let Some(monitor) = MonitorHandle::new(display_id) {
+            Some(monitor)
+        } else {
+            // NOTE: Display ID was just fetched from live NSScreen, but can still result in `None`
+            // with certain Thunderbolt docked monitors.
+            warn!(display_id, "got screen with invalid display ID");
+            None
+        }
     }
 
     #[inline]